Regional anesthetics have evolved into a mainstay of perioperative pain management, providing regionalized analgesia with less systemic side effects. These techniques encompass spinal, epidural, and peripheral nerve blocks that enhance postoperative comfort and enable early mobilization. The use of ultrasound-guided regional anesthesia has improved accuracy, safety, and success rates. The combination of regional anesthesia with multimodal analgesic regimens decreases opioid intake, decreases complication rates, and helps to improve surgical outcomes overall.